Casts : Ellen Pompeo, Sandra Oh, Justin Chambers
When Izzie has a mental collapse after Denny’s death, Izzie and Cristina turn to Meredith to try and make it better for her. Callie tries to cope with George not returning the three word sentiment she said to him. Meanwhile, back at the hospital, Alex and Addison deal with a baby left in a garbage can at a local high school, Richard receives an ultimatum from his wife, and Derek and George are quarantined in the locker room due to a patient suspected of having the plague.
Patients include a teenage boy with a tree run through him, a man with a tumor on his brain that forces him to be honest, and a patient who goes all out on living before her surgery as the interns begin to go all out on Bailey to ask Izzie to come back to Seattle Grace; Dr. Burke’s mother goes all out on breaking Cristina’s will; Addison goes all out with the bottle because she found some interesting pocket fanfare in her husband’s tuxedo after the prom; and Callie goes all out to make George jealous.
Cristina refuses to quit, like she thinks Preston has. Finn and Derek refuse to quit on Meredith, who insist that they date her. Izzie won’t quit standing out front of Seattle Grace, waiting for the time she feels is right to see Dr. Webber. Mark won’t quit on giving up on Addison, who now realizes her marriage to Derek is over. And Alex wishes she would quit picking him as her intern in the OB-GYN department.